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Initiates Phase 1/2a trial of SHP2 inhibitor JAB-3312 in combination with PD-1 antibody Pembrolizumab and MEK inhibitor Binimetinib.
June 18, 2021
By: Kristin Brooks
Managing Editor, Contract Pharma
Jacobio Pharmaceuticals dosed the first two patients in the Phase 1/2a clinical trial of SHP2 inhibitor JAB-3312 in combination with PD-1 antibody Pembrolizumab and MEK inhibitor Binimetinib respectively, triggering a $20 million milestone payment from AbbVie. This is the first milestone payment following the initial upfront fee of $45 million at the outset of the Jacobio/AbbVie’s collaboration. In May 2020, the companies entered an agreement to develop and commercialize SHP2 inhibitor...
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